Activation-Induced Cell Death in Regulatory Expression Confers Resistance to Foxp3-Mediated Suppression of CD95L
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منابع مشابه
Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death.
Most CD4(+)CD25(hi)FOXP3(+) regulatory T cells (T(regs)) from adult peripheral blood express high levels of CD45RO and CD95 and are prone to CD95L-mediated apoptosis in contrast to conventional T cells (T(convs)). However, a T(reg) subpopulation remained consistently apoptosis resistant. Gene microarray and 6-color flow cytometry analysis including FOXP3 revealed an increase in naive T-cell mar...
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تاریخ انتشار 2011